https://www.damienbolton.com.au/home daily 1.0 2026-05-02 https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/1645002399622-MAFK0BKEXWMJ1EF3VNR0/unsplash-image-KrsoedfRAf4.jpg Home https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/cab345a8-0bb4-41b8-b4c7-d8832c0159ec/image+%286%29.png Home https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/7f2400a3-720e-4eba-9908-7ba0f162cd32/robot+console+photo.jpg Home - Professor Damien Bolton is a specialist urologist, with over 25 years experience. Having practiced in private and public hospitals, he has an extensive background in clinical governance, and research in both translational and clinical practice. Dr Bolton has particular interests in management of renal stones, kidney surgery and prostate disease. He has undertaken over 2000 robot assisted operations. https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/fab93aa9-958a-478b-8955-879e8fcc9d1a/Artboard+14+copy+2.png Home https://www.damienbolton.com.au/patient-info daily 0.75 2026-05-02 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg Patient Information https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/1642127114892-ELACK93VY64DBU6Q7FA9/CancerCouncil.jpeg Patient Information https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/1642127155388-P0K6FTIATIP0BTAVKG7R/Screen+Shot+2021-12-30+at+11.40.58+am.png Patient Information https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/1642127272011-A3IW5AT8QVV7973KBD53/AUA+logo.png Patient Information https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/1642127298413-CW474U8YI2SJMQMNJZM8/AUA+logo.png Patient 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About - About Prof. Damien Bolton is a specialist urologist with particular interests in prostate disease and urinary stone disease. He has been in practice for over 25 years and has undertaken over 1000 robot assisted procedures for prostate and kidney cancer. After graduating in Medicine from the University of Melbourne and completing training in urology via the Royal Australasian College of Surgeons he worked at the University of California San Francisco, initially in the position of Clinical Fellow and thereafter as an Assistant Professor. Since returning to Melbourne he has served as Head of Department for Urology at Austin Health since 2000, and has been centrally involved in clinical and translational research since that time. He has served on numerous local, governmental and international committees, and has been a visiting lecturer and/or surgeon in multiple countries including France, USA and China. https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/7c729038-d3a8-4515-8b92-9fd71a0a7d94/MSKCC+with+Marlon+4.23+.PNG About - Genetics in Prostate Cancer Prostate cancer is a complex disease with multiple contributing factors, and extensive research has been conducted to understand its etiology. Among these factors, genetics has been identified as a critical component in the causation of prostate cancer. Numerous studies, supported by robust evidence from published and referenced literature, have highlighted the role of genetic factors in increasing the risk of developing prostate cancer. Family history is a well-established risk factor for prostate cancer. Several large-scale studies have consistently demonstrated that men with a first-degree relative (father, brother) diagnosed with prostate cancer have a significantly higher risk of developing the disease themselves. These findings indicate the presence of hereditary genetic mutations that predispose individuals to prostate cancer. One of the most well-studied genetic markers in prostate cancer is the BRCA gene. While initially recognized for its association with breast and ovarian cancers, research has shown that certain mutations in the BRCA1 and BRCA2 genes also confer an increased risk of prostate cancer in men. The presence of these mutations is particularly noteworthy as they can be inherited from one generation to the next, emphasizing the importance of understanding familial genetic factors. Genome-wide association studies (GWAS) have identified multiple single nucleotide polymorphisms (SNPs) associated with prostate cancer susceptibility. These genetic variants are scattered across the genome and are involved in various cellular processes, including DNA repair, cell cycle regulation, and androgen signaling. The cumulative effect of these SNPs contributes to the overall genetic risk for prostate cancer. Additionally, recent research has focused on somatic mutations occurring within the prostate tumors themselves. Whole-genome sequencing and targeted gene analyses have revealed recurrent genetic alterations in specific genes, such as PTEN, TP53, and NKX3.1, which play crucial roles in prostate cancer development and progression. Furthermore, twin studies have provided further evidence for the heritability of prostate cancer. Identical twins, who share 100% of their genetic material, have a higher concordance rate for prostate cancer compared to non-identical twins, underscoring the genetic contribution to disease risk. The available published and referenced literature strongly supports the role of genetics in the causation of prostate cancer. The evidence highlights the importance of understanding genetic factors in identifying individuals at higher risk, enabling early detection and personalized treatment strategies. I regularly arrange genetic testing where it can influence patient management, and believe it is crucial to emphasise the significance of genetic screening and counselling for individuals with a family history of prostate cancer to improve patient outcomes through early intervention and targeted therapies. Genetic screening is widely available in Australia and under some circumstances can be rebated via Medicare. The key factors in the use of this information are choosing when this test is going to provide information of relevance, and how to interpret the results of genetic assessments. https://images.squarespace-cdn.com/content/v1/61b19c0d4f41d809b2365042/d7ce347d-63d4-4c00-85fb-77c81abbbdb8/Artboard+14+copy+2.png About - Make it stand out Whatever it is, the way you tell your story online can make all the difference.